CAS 9004-65-3

Nulose

Hypromellose. Hydroxypropyl Methyl Cellulose (HPMC)

Applications

Nulose HPMC are high-functionality excipients used mainly as binders, thickeners, dispersants, emulsifiers, film formers, and suspending agents. Nulose HPMC is effective for film coatings, vegetarian capsules, and controlled-release applications.

For food and cosmetics applications, Nulose HPMC can act as a film former, thickener, binder, humectant, and thermal gelation agent to improve stability, texture, and sensory.

Technical Specification

Complies with USP/NF and EP

Application: Tablets and Capsules

Nulose is an ideal excipient for immediate release film coatings, controlled release tablet matrixes, and tablet binders. Low viscosity grades of Nulose are multi-purposes in pharmaceutical and nutritional supplement dosage forms.

Binder

Nulose can be used as a wet granulation binder in solution. Low use rates (1-5% of the tablet weight) minimize tablet size. The use of HPMC as a binder to produce granules to make a better flowing and more compressible blend, will lead to improved content uniformity.

Packaging

25 kg polyethylene bag in a fiber drum.

Preparation of Nulose Solution

Nulose is soluble in water, alcohol, or organic solvent mixtures (such as dichloromethane / alcohol). The appropriate liquid should be stirred in the mixing kettle, and then Nulose should be added ensuring the particles are well-dispersed and do not clump. Proper dispersion of Nulose is necessary to provide the fastest dissolution. The well dispersed particles will dissolve in cold water in 30 – 60 minutes.

Film Coating

Nulose is widely utilized in immediate release tablets coatings. A clear coating formulation consists of Nulose combined with appropriate plasticizer, such as polyethylene glycol, triethyl citrate, triacetin, or glycerin to yield an aqueous or solvent dispersion of 5% to 15% solids. The plasticizer should comprise 5% – 25% of the polymer. Pigments such as titanium dioxide, iron oxides, or aluminum lakes may be added at 25% to 50% of the weight of the polymer.

Basic wet granulation procedure

  • Prepare an aqueous solution of Nulose (10-15%)
  • Blend the API, tablet excipients, and Nulose solution in a high shear granulator.
  • Dry the granules and mill to the appropriate size.
  • Blend the granules with lubricant and any remaining excipients.
  • Compress tablets to desired characteristics.

Application: Ointments, Gels and Creams

Higher viscosity grades of Nulose are used as a thickening agent in ointments, gels, and creams. Nulose can be used in gel drug formulations to prevent water separation.