CAS 9004-65-3


Hypromellose. Hydroxypropyl Methyl Cellulose (HPMC)


Nulose is a pharmaceutical excipient with multi-functional properties and can be used mainly as a thickener, dispersant, emulsifier, suspending, and film-forming agent. It is primarily used as a coating polymer, controlled release agent, and binder in pharmaceutical tablets. It is used in pharmaceutical suspensions such as ophthalmic preparations. It can also improve the rheological properties in food and cosmetics products. Also, it is the main ingredient in the manufacturing process of vegetable capsules.

Technical Specification

Complies with USP/NF and EP

Application: Tablets and Capsules

Nulose is an ideal excipient for immediate release film coatings, controlled release tablet matrixes, and tablet binders. Low viscosity grades of Nulose are multi-purposes in pharmaceutical and nutritional supplement dosage forms.


Nulose can be used as a wet granulation binder in solution. Low use rates (1-5% of the tablet weight) minimize tablet size. The use of HPMC as a binder to produce granules to make a better flowing and more compressible blend, will lead to improved content uniformity.


25 kg polyethylene bag in a fiber drum.

Preparation of Nulose Solution

Nulose is soluble in water, alcohol, or organic solvent mixtures (such as dichloromethane / alcohol). The appropriate liquid should be stirred in the mixing kettle, and then Nulose should be added ensuring the particles are well-dispersed and do not clump. Proper dispersion of Nulose is necessary to provide the fastest dissolution. The well dispersed particles will dissolve in cold water in 30 – 60 minutes.

Film Coating

Nulose is widely utilized in immediate release tablets coatings. A clear coating formulation consists of Nulose combined with appropriate plasticizer, such as polyethylene glycol, triethyl citrate, triacetin, or glycerin to yield an aqueous or solvent dispersion of 5% to 15% solids. The plasticizer should comprise 5% – 25% of the polymer. Pigments such as titanium dioxide, iron oxides, or aluminum lakes may be added at 25% to 50% of the weight of the polymer.

Basic wet granulation procedure

  • Prepare an aqueous solution of Nulose (10-15%)
  • Blend the API, tablet excipients, and Nulose solution in a high shear granulator.
  • Dry the granules and mill to the appropriate size.
  • Blend the granules with lubricant and any remaining excipients.
  • Compress tablets to desired characteristics.

Application: Ointments, Gels and Creams

Higher viscosity grades of Nulose are used as a thickening agent in ointments, gels, and creams. Nulose can be used in gel drug formulations to prevent water separation.